Highly reliable GIGA-sized synthetic human therapeutic antibody library construction

Highly reliable GIGA-sized synthetic human therapeutic antibody library construction

BackgroundMonoclonal antibodies (mAbs) and their derivatives are the fastest expanding category of pharmaceuticals. Efficient screening and generation of appropriate therapeutic human antibodies are important and urgent issues in the field of medicine. The successful in vitro biopanning method for a...

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Bibliographic Details
Main Authors: Chao-Yang Huang, Ying-Yung Lok, Chia-Hui Lin, Szu-Liang Lai, Yen-Yu Wu, Chih-Yung Hu, Chu-Bin Liao, Chen-Hsuan Ho, Yu-Ping Chou, Yi-Hsuan Hsu, Yu-Hsun Lo, Edward Chern
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
phage display
single-chain variable fragment (scFv)
synthetic antibody library
antibody therapeutics
TIM-3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1089395/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1089395/full

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