Synergistic Anti-Tumor Effect of Simvastatin Combined to Chemotherapy in Osteosarcoma

Synergistic Anti-Tumor Effect of Simvastatin Combined to Chemotherapy in Osteosarcoma

Context: Osteosarcoma is the most common primary solid malignancy of the bone, mainly affecting pediatric patients. The main clinical issues are chemoresistance and metastatic spread, leading to a survival rate stagnating around 60% for four decades. Purpose: Here, we investigated the effect of simv...

Full description

Bibliographic Details
Main Authors: Adèle Mangelinck, Nadia Habel, Audrey Mohr, Nathalie Gaspar, Bojana Stefanovska, Olivia Fromigué
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cancers
Subjects:
chemoresistance
adjuvant therapy
bone tumor
invasion
mevalonate pathway
statin
Online Access:https://www.mdpi.com/2072-6694/13/22/5869

Internet

https://www.mdpi.com/2072-6694/13/22/5869

Similar Items