Homologous Recombination Abnormalities Associated With Mutations as Predicted by Machine Learning of Targeted Next-Generation Sequencing Data
Background: Homologous recombination deficiency (HRD) is the hallmark of breast cancer gene 1/2 ( BRCA1/2 )-mutated tumors and the unique biomarker for predicting response to double-strand break (DSB)–inducing drugs. The demonstration of HRD in tumors with mutations in genes other than BRCA1/2 is co...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2023-09-01
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Series: | Breast Cancer: Basic and Clinical Research |
Online Access: | https://doi.org/10.1177/11782234231198979 |