Homologous Recombination Abnormalities Associated With Mutations as Predicted by Machine Learning of Targeted Next-Generation Sequencing Data

Homologous Recombination Abnormalities Associated With Mutations as Predicted by Machine Learning of Targeted Next-Generation Sequencing Data

Background: Homologous recombination deficiency (HRD) is the hallmark of breast cancer gene 1/2 ( BRCA1/2 )-mutated tumors and the unique biomarker for predicting response to double-strand break (DSB)–inducing drugs. The demonstration of HRD in tumors with mutations in genes other than BRCA1/2 is co...

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Bibliographic Details
Main Authors: Maher Albitar, Hong Zhang, Andrew Pecora, Stanley Waintraub, Deena Graham, Mira Hellmann, Donna McNamara, Ahmad Charifa, Ivan De Dios, Wanlong Ma, Andre Goy
Format: Article
Language:English
Published: SAGE Publishing 2023-09-01
Series:Breast Cancer: Basic and Clinical Research
Online Access:https://doi.org/10.1177/11782234231198979

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