Compartmentation of Metabolites in Regulating Epigenomes of Cancer

Abstract Covalent modifications of DNA and histones are important epigenetic events and the genomewide reshaping of epigenetic markers is common in cancer. Epigenetic markers are produced by enzymatic reactions, and some of these reactions require the presence of metabolites, specifically Epigenetic...

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Bibliographic Details
Main Authors: Zhiqiang Zhao, Li Wang, Li-jun Di
Format: Article
Language:English
Published: BMC 2016-04-01
Series:Molecular Medicine
Online Access:http://link.springer.com/article/10.2119/molmed.2016.00051