Interactions of human autoantibodies with hippocampal GABAergic synaptic transmission – analyzing antibody-induced effects ex-vivo

Interactions of human autoantibodies with hippocampal GABAergic synaptic transmission – analyzing antibody-induced effects ex-vivo

Autoantibodies (aAB) to the presynaptic located enzyme glutamate decarboxylase 65 (GAD65) are a characteristic attribute for a variety of autoimmune diseases of the central nervous system including subtypes of limbic encephalitis, stiff person-syndrome, cerebellar ataxia, and Batten´s disease. Clini...

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Bibliographic Details
Main Authors: Holger eHaselmann, Luise eRöpke, Christian eWerner, Albrecht eKunze, Christian eGeis
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Neurology
Subjects:
Hippocampus
Limbic Encephalitis
Autoantibody
GABAergic inhibition
patch-clamp recording
GAD65
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00136/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00136/full

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