Stereoselective chemo-enzymatic oxidation routes for (1R,3E,7E,11S,12S)-3,7,18-dolabellatriene

Stereoselective chemo-enzymatic oxidation routes for (1R,3E,7E,11S,12S)-3,7,18-dolabellatriene

The diterpene (1R,3E,7E,11S,12S)-3,7,18-dolabellatriene from the marine brown alga Dilophus spiralis belongs to the dolabellanes natural product family and has antimicrobial activity against multi-drug resistant Staphylococcus aureus (MRSA). Recently, we generated a CotB2 diterpene synthase mutant (...

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Bibliographic Details
Main Authors: Christian eGörner, Max eHirte, Stephanie eHuber, Patrick eSchrepfer, Thomas Bartholomäus Brück
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Microbiology
Subjects:
Diterpenes
Epoxidation
Chemo-enzymatic Synthesis
hydroboration
Dolabellanes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01115/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01115/full

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