Liver sinusoidal endothelial cells show reduced scavenger function and downregulation of Fc gamma receptor IIb, yet maintain a preserved fenestration in the Glmpgt/gt mouse model of slowly progressing liver fibrosis.

Liver sinusoidal endothelial cells show reduced scavenger function and downregulation of Fc gamma receptor IIb, yet maintain a preserved fenestration in the Glmpgt/gt mouse model of slowly progressing liver fibrosis.

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Liver sinusoidal endothelial cells (LSECs) are fenestrated endothelial cells with a unique, high endocytic clearance capacity for blood-borne waste macromolecules and colloids. This LSEC scavenger function has been insufficiently characterized in liver disease. The Glmpgt/gt mouse lacks expression o...

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Bibliographic Details
Main Authors: Milton Boaheng Antwi, Gianina Dumitriu, Jaione Simón-Santamaria, Javier Sánchez Romano, Ruomei Li, Bård Smedsrød, Anders Vik, Winnie Eskild, Karen Kristine Sørensen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293526&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293526&type=printable

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