Antibodies to PcpA and PhtD protect mice against Streptococcus pneumoniae by a macrophage- and complement-dependent mechanism

Antibodies to PcpA and PhtD protect mice against Streptococcus pneumoniae by a macrophage- and complement-dependent mechanism

Currently marketed Streptococcus pneumoniae (Spn) vaccines, which contain polysaccharide capsular antigens from the most common Spn serotypes, have substantially reduced pneumococcal disease rates but have limited coverage. A trivalent pneumococcal protein vaccine containing pneumococcal choline-bin...

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Bibliographic Details
Main Authors: Lucian Visan, Nicolas Rouleau, Emilie Proust, Loïc Peyrot, Arnaud Donadieu, Martina Ochs
Format: Article
Language:English
Published: Taylor & Francis Group 2018-02-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
antibody
complement
macrophage
neutrophil
opsonophagocytosis
phagocytosis
streptococcus pneumoniae
vaccination
Online Access:http://dx.doi.org/10.1080/21645515.2017.1403698

Internet

http://dx.doi.org/10.1080/21645515.2017.1403698

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