New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells

New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells

Colorectal cancer: Antitumor antidepressant The antidepressant drug imipramine can block the activity of a protein that contributes to the progression of certain aggressive tumors. Serrated adenocarcinoma (SAC) is a form of colorectal cancer with a poor prognosis. A key factor in SAC development is...

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Bibliographic Details
Main Authors: Begoña Alburquerque-González, Manuel Bernabé-García, Silvia Montoro-García, Ángel Bernabé-García, Priscila Campioni Rodrigues, Javier Ruiz Sanz, Fernando F. López-Calderón, Irene Luque, Francisco José Nicolas, María Luisa Cayuela, Tuula Salo, Horacio Pérez-Sánchez, Pablo Conesa-Zamora
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-020-0389-x

Internet

https://doi.org/10.1038/s12276-020-0389-x

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