Site-oriented conjugation of poly(2-methacryloyloxyethyl phosphorylcholine) for enhanced brain delivery of antibody

Site-oriented conjugation of poly(2-methacryloyloxyethyl phosphorylcholine) for enhanced brain delivery of antibody

Antibody therapeutics are limited in treating brain diseases due to poor blood-brain barrier (BBB) penetration. We have discovered that poly 2-methacryloyloxyethyl phosphorylcholine (PMPC), a biocompatible polymer, effectively facilitates BBB penetration via receptor-mediated transcytosis and have d...

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Bibliographic Details
Main Authors: Jie Ren, Chloe E. Jepson, Sarah L. Nealy, Charles J. Kuhlmann, Satoru Osuka, Stella Uloma Azolibe, Madison T. Blucas, Yoshiko Nagaoka-Kamata, Eugenia Kharlampieva, Masakazu Kamata
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
antibody
brain disease
trastuzumab
biofunctionality
poly 2-methacryloyloxyethyl phosphorylcholine
site-oriented conjugation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1214118/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1214118/full

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