Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction

Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction

Summary: Myocardial infarction (MI)−induced cardiac fibrosis attenuates cardiac contractile function, and predisposes to arrhythmias and sudden cardiac death. Expression of connective tissue growth factor (CTGF) is elevated in affected organs in virtually every fibrotic disorder and in the diseased...

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Main Authors: Laura E. Vainio, MD, Zoltán Szabó, MSc, Ruizhu Lin, MSc, Johanna Ulvila, PhD, Raisa Yrjölä, MSc, Tarja Alakoski, MSc, Jarkko Piuhola, MD, PhD, Walter J. Koch, PhD, Heikki Ruskoaho, MD, PhD, Shaun D. Fouse, PhD, Todd W. Seeley, PhD, Erhe Gao, MD, PhD, Pierre Signore, PhD, Kenneth E. Lipson, PhD, Johanna Magga, PhD, Risto Kerkelä, MD, PhD
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X18302778

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http://www.sciencedirect.com/science/article/pii/S2452302X18302778

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