Activation of Wnt/β-catenin signaling increases apoptosis in melanoma cells treated with trail.

Activation of Wnt/β-catenin signaling increases apoptosis in melanoma cells treated with trail.

While the TRAIL pathway represents a promising therapeutic target in melanoma, resistance to TRAIL-mediated apoptosis remains a barrier to its successful adoption. Since the Wnt/β-catenin pathway has been implicated in facilitating melanoma cell apoptosis, we investigated the effect of Wnt/β-catenin...

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Bibliographic Details
Main Authors: Zachary F Zimmerman, Rima M Kulikauskas, Karol Bomsztyk, Randall T Moon, Andy J Chien
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3711908?pdf=render

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http://europepmc.org/articles/PMC3711908?pdf=render

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