Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen, Trypanosoma cruzi

Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen, Trypanosoma cruzi

Trypanosoma cruzi, a zoonotic kinetoplastid protozoan parasite, is the causative agent of American trypanosomiasis (Chagas disease). Having a very plastic, repetitive and complex genome, the parasite displays a highly diverse repertoire of surface molecules, with pivotal roles in cell invasion, immu...

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Main Authors: Carlos Talavera-López, Louisa A. Messenger, Michael D. Lewis, Matthew Yeo, João Luís Reis-Cunha, Gabriel Machado Matos, Daniella C. Bartholomeu, José E. Calzada, Azael Saldaña, Juan David Ramírez, Felipe Guhl, Sofía Ocaña-Mayorga, Jaime A. Costales, Rodion Gorchakov, Kathryn Jones, Melissa S. Nolan, Santuza M. R. Teixeira, Hernán José Carrasco, Maria Elena Bottazzi, Peter J. Hotez, Kristy O. Murray, Mario J. Grijalva, Barbara Burleigh, Edmundo C. Grisard, Michael A. Miles, Björn Andersson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Trypanosoma cruzi
genome sequence
antigenic variation
population genetics
parasitology
microbial genomics
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.614665/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.614665/full

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