Mesenchymal stem cell-derived exosomal miR-146a reverses diabetic β-cell dedifferentiation

Mesenchymal stem cell-derived exosomal miR-146a reverses diabetic β-cell dedifferentiation

Abstract Background Mesenchymal stem cells (MSCs) show promising therapeutic potential in treating type 2 diabetes mellitus (T2DM) in clinical studies. Accumulating evidence has suggested that the therapeutic effects of MSCs are not due to their direct differentiation into functional β-cells but are...

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Bibliographic Details
Main Authors: Qin He, Jia Song, Chen Cui, Jinbang Wang, Huiqing Hu, Xinghong Guo, Mengmeng Yang, Lingshu Wang, Fei Yan, Kai Liang, Zhaojian Liu, Fuqiang Liu, Zheng Sun, Ming Dong, Xinguo Hou, Li Chen
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Stem Cell Research & Therapy
Subjects:
Exosome
Mesenchymal stem cell
Type 2 diabetes mellitus
β-cell dedifferentiation
miR-146a
Online Access:https://doi.org/10.1186/s13287-021-02371-0

Internet

https://doi.org/10.1186/s13287-021-02371-0

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