IGF1R, IGFALS, and IGFBP3 gene copy number variations in a group of non-syndromic Egyptian short children

IGF1R, IGFALS, and IGFBP3 gene copy number variations in a group of non-syndromic Egyptian short children

Abstract Background Insulin-like growth factor-1 (IGF-1) is required for normal intrauterine and postnatal growth, and this action is mediated through IGF1 receptor (IGF1R). IGF1R copy number variants (CNVs) can cause pre- and postnatal growth restriction, affecting an individual’s height. In this s...

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Bibliographic Details
Main Authors: Islam M. Fadel, Moustafa H. Ragab, Ola M. Eid, Nivine A. Helmy, Hala T. El-Bassyouni, Inas Mazen
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Journal of Genetic Engineering and Biotechnology
Subjects:
Short stature
Copy number variations (CNVs)
Multiplex ligation-dependent probe amplification (MLPA)
IGF1R
ALS
IGFBP3
Online Access:https://doi.org/10.1186/s43141-021-00202-6

Internet

https://doi.org/10.1186/s43141-021-00202-6

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