p16INK4a Expression and Absence of Activated B-RAF Are Independent Predictors of Chemosensitivity in Melanoma Tumors

p16INK4a Expression and Absence of Activated B-RAF Are Independent Predictors of Chemosensitivity in Melanoma Tumors

Metastatic cutaneous melanoma is highly resistant to cytotoxic drugs, and this contributes to poor prognosis. In vivo studies on the chemosensitivity of metastatic melanoma are rare and hampered by poor response rates to systemic chemotherapeutics. Patients who undergo isolated limb infusion (ILI) w...

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Bibliographic Details
Main Authors: Stuart J. Gallagher, John F. Thompson, James Indsto, Lyndee L. Scurr, Margaret Lett, Bo-Fu Gao, Ruth Dunleavey, Graham J. Mann, Richard F. Kefford, Helen Rizos
Format: Article
Language:English
Published: Elsevier 2008-11-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558608800206

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http://www.sciencedirect.com/science/article/pii/S1476558608800206

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