Impact of the SARS-CoV-2 nucleocapsid 203K/204R mutations on the inflammatory immune response in COVID-19 severity

Impact of the SARS-CoV-2 nucleocapsid 203K/204R mutations on the inflammatory immune response in COVID-19 severity

Abstract Background The excessive inflammatory responses provoked by SARS-CoV-2 infection are critical factors affecting the severity and mortality of COVID-19. Previous work found that two adjacent co-occurring mutations R203K and G204R (KR) on the nucleocapsid (N) protein correlate with increased...

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Bibliographic Details
Main Authors: Muhammad Shuaib, Sabir Adroub, Tobias Mourier, Sara Mfarrej, Huoming Zhang, Luke Esau, Afrah Alsomali, Fadwa S Alofi, Adeel Nazir Ahmad, Abbas Shamsan, Asim Khogeer, Anwar M. Hashem, Naif A. M. Almontashiri, Sharif Hala, Arnab Pain
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Genome Medicine
Subjects:
COVID-19
SARS-CoV-2
Variant of concern
Nucleocapsid (N) R203K/G204R (KR) mutations
Virus-like particle (VLP)
Transcriptomics
Online Access:https://doi.org/10.1186/s13073-023-01208-0

Internet

https://doi.org/10.1186/s13073-023-01208-0

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