Safety, Immunogenicity, and Mechanism of a Rotavirus mRNA-LNP Vaccine in Mice

Safety, Immunogenicity, and Mechanism of a Rotavirus mRNA-LNP Vaccine in Mice

Rotaviruses (RVs) are a major cause of diarrhea in young children worldwide. The currently available and licensed vaccines contain live attenuated RVs. Optimization of live attenuated RV vaccines or developing non-replicating RV (e.g., mRNA) vaccines is crucial for reducing the morbidity and mortali...

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Bibliographic Details
Main Authors: Chenxing Lu, Yan Li, Rong Chen, Xiaoqing Hu, Qingmei Leng, Xiaopeng Song, Xiaochen Lin, Jun Ye, Jinlan Wang, Jinmei Li, Lida Yao, Xianqiong Tang, Xiangjun Kuang, Guangming Zhang, Maosheng Sun, Yan Zhou, Hongjun Li
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Viruses
Subjects:
rotavirus
mRNA vaccine
structural protein VP7
lipid nanoparticles
neutralizing antibody
Online Access:https://www.mdpi.com/1999-4915/16/2/211

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https://www.mdpi.com/1999-4915/16/2/211

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