Deficiency of AP1 Complex <i>Ap1g1</i> in Zebrafish Model Led to Perturbation of Neurodevelopment, Female and Male Fertility; New Insight to Understand Adaptinopathies

Deficiency of AP1 Complex <i>Ap1g1</i> in Zebrafish Model Led to Perturbation of Neurodevelopment, Female and Male Fertility; New Insight to Understand Adaptinopathies

In vertebrates, two homologous heterotetrameric AP1 complexes regulate the intracellular protein sorting via vesicles. AP-1 complexes are ubiquitously expressed and are composed of four different subunits: γ, β1, μ1 and σ1. Two different complexes are present in eukaryotic cells, AP1G1 (contains γ1...

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Bibliographic Details
Main Authors: Luca Mignani, Nicola Facchinello, Marco Varinelli, Elena Massardi, Natascia Tiso, Cosetta Ravelli, Stefania Mitola, Peter Schu, Eugenio Monti, Dario Finazzi, Giuseppe Borsani, Daniela Zizioli
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
intracellular vesicular trafficking
adaptinopathies
embryonic development
CRISPR/Cas9 technique
Online Access:https://www.mdpi.com/1422-0067/24/8/7108

Internet

https://www.mdpi.com/1422-0067/24/8/7108

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