A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases

A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases

Abstract Multiple neurodegenerative diseases are characterized by aggregation of tau molecules. Adult humans express six isoforms of tau that contain either 3 or 4 microtubule binding repeats (3R or 4R tau). Different diseases involve preferential aggregation of 3R (e.g Pick disease), 4R (e.g. progr...

Full description

Bibliographic Details
Main Authors: Michael A. Metrick, Natália do Carmo Ferreira, Eri Saijo, Allison Kraus, Kathy Newell, Gianluigi Zanusso, Michele Vendruscolo, Bernardino Ghetti, Byron Caughey
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Acta Neuropathologica Communications
Subjects:
RT-QuIC
Tau
Pick disease
Alzheimer disease
Chronic traumatic encephalopathy
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s40478-020-0887-z

Internet

http://link.springer.com/article/10.1186/s40478-020-0887-z

Similar Items