Oral or intranasal immunization with recombinant Lactobacillus plantarum displaying head domain of Swine Influenza A virus hemagglutinin protects mice from H1N1 virus

Oral or intranasal immunization with recombinant Lactobacillus plantarum displaying head domain of Swine Influenza A virus hemagglutinin protects mice from H1N1 virus

Abstract Background Swine influenza A virus (swIAV) is a major concern for the swine industry owing to its highly contagious nature and acute viral disease. Currently, most commercial swIAV vaccines are traditional inactivated virus vaccines. The Lactobacillus plantarum-based vaccine platform is a p...

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Bibliographic Details
Main Authors: Yufei Zhang, Li Yang, Jiali Zhang, Kun Huang, Xiaomei Sun, Ying Yang, Ting Wang, Qiang Zhang, Zhong Zou, Meilin Jin
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Microbial Cell Factories
Subjects:
Swine Influenza A virus
Lactobacillus plantarum
Mucosal immunity
Intranasal immunization
Oral immunization
Online Access:https://doi.org/10.1186/s12934-022-01911-4

Internet

https://doi.org/10.1186/s12934-022-01911-4

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