Pathogenic germline variants in SMARCA4 and further cancer predisposition genes in early onset ovarian cancer

Pathogenic germline variants in SMARCA4 and further cancer predisposition genes in early onset ovarian cancer

To assess the role of germline pathogenic variants (PVs) in SMARCA4 and further established ovarian cancer (OC) predisposition genes in early onset OC, we investigated a clinical cohort of 206 unrelated OC index patients with an age at diagnosis of OC ≤40 years using an extended panel of 24 (candida...

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Bibliographic Details
Main Authors: Natalie Herold, Johanna Schmolling, Corinna Ernst, Beyhan Ataseven, Britta Blümcke, Birgid Schömig‐Markiefka, Sebastian Heikaus, Uwe‐Jochen Göhring, Christoph Engel, Björn Lampe, Kerstin Rhiem, Philipp Harter, Jan Hauke, Rita K. Schmutzler, Eric Hahnen
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Cancer Medicine
Subjects:
BRCA mutations
cancer risk factors
gynecological oncology
hereditary cancer
ovarian cancer
SCCOHT
Online Access:https://doi.org/10.1002/cam4.6214

Internet

https://doi.org/10.1002/cam4.6214

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