Immunological and prognostic analysis of PSENEN in low-grade gliomas: An immune infiltration-related prognostic biomarker

Immunological and prognostic analysis of PSENEN in low-grade gliomas: An immune infiltration-related prognostic biomarker

Metformin is widely used in the treatment of type 2 diabetes (T2D) and plays a role in antitumor and antiobesity processes. A recent study identified its direct molecular target, PEN2 (PSENEN). PSENEN is the minimal subunit of the multiprotein complex γ-secretase, which promotes the differentiation...

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Bibliographic Details
Main Authors: Kaijie Chen, Beibei Liang, Wenhao Ma, Guoqing Wan, Bing Chen, Changlian Lu, Yuzhou Luo, Xuefeng Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
PEN2 (PSENEN)
metformin
low-grade glioma
prognosis
immune infiltration
macrophage M2
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.933855/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2022.933855/full

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