A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells

A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells

Recognition and elimination of tumor cells by the immune system is crucial for limiting tumor growth. Natural killer (NK) cells become activated when the receptor NKG2D is engaged by ligands that are frequently upregulated in primary tumors and on cancer cell lines. However, the molecular mechanisms...

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Bibliographic Details
Main Authors: Benjamin G Gowen, Bryan Chim, Caleb D Marceau, Trever T Greene, Patrick Burr, Jeanmarie R Gonzalez, Charles R Hesser, Peter A Dietzen, Teal Russell, Alexandre Iannello, Laurent Coscoy, Charles L Sentman, Jan E Carette, Stefan A Muljo, David H Raulet
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-11-01
Series:eLife
Subjects:
tumor immunology
natural killer cells
NKG2D
cellular stress
CRISPR/Cas9
alternative splicing
Online Access:https://elifesciences.org/articles/08474

Internet

https://elifesciences.org/articles/08474

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