Systematic In Vitro Evaluation of a Library of Approved and Pharmacologically Active Compounds for the Identification of Novel Candidate Drugs for KMT2A-Rearranged Leukemia

Systematic In Vitro Evaluation of a Library of Approved and Pharmacologically Active Compounds for the Identification of Novel Candidate Drugs for KMT2A-Rearranged Leukemia

Patients whose leukemias harbor a rearrangement of the Mixed Lineage Leukemia (MLL/KMT2A) gene have a poor prognosis, especially when the disease strikes in infants. The poor clinical outcome linked to this aggressive disease and the detrimental treatment side-effects, particularly in children, warr...

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Bibliographic Details
Main Authors: Mawar Karsa, Emma Ronca, Angelika Bongers, Anna Mariana, Ernest Moles, Timothy W. Failes, Greg M. Arndt, Laurence C. Cheung, Rishi S. Kotecha, Maria Kavallaris, Michelle Haber, Murray D. Norris, Michelle J. Henderson, Lin Xiao, Klaartje Somers
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Oncology
Subjects:
KMT2A/MLL-rearranged leukemia
infant leukemia
repurposing
high-throughput screen
NR5A1
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.779859/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.779859/full

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