Inhibition of lysyl oxidase by pharmacological intervention and genetic manipulation alleviates epilepsy-associated cognitive disorder

Inhibition of lysyl oxidase by pharmacological intervention and genetic manipulation alleviates epilepsy-associated cognitive disorder

Epilepsy-associated cognitive disorder (ECD), a prevalent comorbidity in epilepsy patients, has so far uncharacterized etiological origins. Our prior work revealed that lysyl oxidase (Lox) acted as a novel contributor of ferroptosis, a recently discovered cell death mode in the regulation of brain f...

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Bibliographic Details
Main Authors: Kang-Ni Chen, Qi-Lin Peng, Dan-Feng Cao, Zhao-Jun Wang, Kai Zhang, Xin-Yu Zhou, Dong-Yu Min, Bo-Ting Zhou, Xiao-Yuan Mao
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Brain Research Bulletin
Subjects:
Epilepsy-associated cognitive disorder
ferroptosis
Lysyl oxidase
β-aminopropionitrile
genetic manipulation
therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923024000613

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http://www.sciencedirect.com/science/article/pii/S0361923024000613

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