Network quantification of EGFR signaling unveils potential for targeted combination therapy

Network quantification of EGFR signaling unveils potential for targeted combination therapy

The epidermal growth factor receptor (EGFR) signaling network is activated in most solid tumors, and small‐molecule drugs targeting this network are increasingly available. However, often only specific combinations of inhibitors are effective. Therefore, the prediction of potent combinatorial treatm...

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Bibliographic Details
Main Authors: Bertram Klinger, Anja Sieber, Raphaela Fritsche‐Guenther, Franziska Witzel, Leanne Berry, Dirk Schumacher, Yibing Yan, Pawel Durek, Mark Merchant, Reinhold Schäfer, Christine Sers, Nils Blüthgen
Format: Article
Language:English
Published: Springer Nature 2013-01-01
Series:Molecular Systems Biology
Subjects:
cancer
EGFR signaling
mathematical modeling
modular response analysis
signal transduction
Online Access:https://doi.org/10.1038/msb.2013.29

Internet

https://doi.org/10.1038/msb.2013.29

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