Identification of Recessive Lethal Alleles in the Diploid Genome of a <named-content content-type="genus-species">Candida albicans</named-content> Laboratory Strain Unveils a Potential Role of Repetitive Sequences in Buffering Their Deleterious Impact

Identification of Recessive Lethal Alleles in the Diploid Genome of a <named-content content-type="genus-species">Candida albicans</named-content> Laboratory Strain Unveils a Potential Role of Repetitive Sequences in Buffering Their Deleterious Impact

ABSTRACT The heterozygous diploid genome of Candida albicans is highly plastic, with frequent loss of heterozygosity (LOH) events. In the SC5314 laboratory strain, while LOH events are ubiquitous, a chromosome homozygosis bias is observed for certain chromosomes, whereby only one of the two homologs...

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Bibliographic Details
Main Authors: Timea Marton, Adeline Feri, Pierre-Henri Commere, Corinne Maufrais, Christophe d’Enfert, Melanie Legrand
Format: Article
Language:English
Published: American Society for Microbiology 2019-02-01
Series:mSphere
Subjects:
Candida albicans
homologous recombination
loss of heterozygosity
major repeat sequences
recessive lethal alleles
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00709-18

Internet

https://journals.asm.org/doi/10.1128/mSphere.00709-18

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