Low-Dose Irradiation Promotes Persistent Oxidative Stress and Decreases Self-Renewal in Hematopoietic Stem Cells

Low-Dose Irradiation Promotes Persistent Oxidative Stress and Decreases Self-Renewal in Hematopoietic Stem Cells

Despite numerous observations linking protracted exposure to low-dose (LD) radiation and leukemia occurrence, the effects of LD irradiation on hematopoietic stem cells (HSCs) remain poorly documented. Here, we show that adult HSCs are hypersensitive to LD irradiation. This hyper-radiosensitivity is...

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Bibliographic Details
Main Authors: Sarah Rodrigues-Moreira, Stéphanie G. Moreno, Giulia Ghinatti, Daniel Lewandowski, Françoise Hoffschir, Federica Ferri, Anne-Sophie Gallouet, Denise Gay, Hozumi Motohashi, Masayuki Yamamoto, Michael C. Joiner, Nathalie Gault, Paul-Henri Romeo
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
low-dose irradiation
hematopoietic stem cell
bone marrow transplantation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312743

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http://www.sciencedirect.com/science/article/pii/S2211124717312743

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