Role of Mitochondrial Iron Uptake in Acetaminophen Hepatotoxicity
Overdose of acetaminophen (APAP) produces fulminant hepatic necrosis. The underlying mechanism of APAP hepatotoxicity involves mitochondrial dysfunction, including mitochondrial oxidant stress and the onset of mitochondrial permeability transition (MPT). Reactive oxygen species (ROS) play an importa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-07-01
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| Series: | Livers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4389/4/3/24 |