Comparison of the Effects of Chemokine Receptors CXCR2 and CXCR3 Pharmacological Modulation in Neuropathic Pain Model—<i>In Vivo</i> and <i>In Vitro</i> Study

Comparison of the Effects of Chemokine Receptors CXCR2 and CXCR3 Pharmacological Modulation in Neuropathic Pain Model—<i>In Vivo</i> and <i>In Vitro</i> Study

Recent findings have highlighted the roles of CXC chemokine family in the mechanisms of neuropathic pain. Our studies provide evidence that single/repeated intrathecal administration of CXCR2 (NVP-CXCR2-20) and CXCR3 ((±)-NBI-74330) antagonists explicitly attenuated mechanical/thermal hypersensitivi...

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Bibliographic Details
Main Authors: Anna Piotrowska, Katarzyna Ciapała, Katarzyna Pawlik, Klaudia Kwiatkowski, Ewelina Rojewska, Joanna Mika
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
neuroinflammation
chemokines
cytokines
neurodegeneration
glial cells
Online Access:https://www.mdpi.com/1422-0067/22/20/11074

Internet

https://www.mdpi.com/1422-0067/22/20/11074

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