Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

Exposure to the herbicide paraquat (PQ) is associated with an increased risk of idiopathic Parkinson’s disease (PD). Therapies based on PQ’s presumed mechanisms of action have not, however, yielded effective disease therapies. Cellular senescence is an anticancer mechanism that arrests proliferation...

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Bibliographic Details
Main Authors: Shankar J. Chinta, Georgia Woods, Marco Demaria, Anand Rane, Ying Zou, Amanda McQuade, Subramanian Rajagopalan, Chandani Limbad, David T. Madden, Judith Campisi, Julie K. Andersen
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
aging
antagonistic pleiotropy
neurodegeneration
senescence-associated secretory phenotype
tumor suppression
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717319290

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http://www.sciencedirect.com/science/article/pii/S2211124717319290

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