Full-length versus truncated α-factor secretory signal sequences for expression of recombinant human insulin precursor in yeast Pichia pastoris: a comparison

Full-length versus truncated α-factor secretory signal sequences for expression of recombinant human insulin precursor in yeast Pichia pastoris: a comparison

Abstract Background Human insulin was the first FDA-approved biopharmaceutical drug produced through recombinant DNA technology. The previous studies successfully expressed recombinant human insulin precursors (HIP) in Pichia pastoris truncated and full-length α-factor recombinant clones. The mattin...

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Bibliographic Details
Main Authors: Nuruliawaty Utami, Dini Nurdiani, Hariyatun Hariyatun, Eko Wahyu Putro, Fadillah Putri Patria, Wien Kusharyoto
Format: Article
Language:English
Published: SpringerOpen 2023-05-01
Series:Journal of Genetic Engineering and Biotechnology
Subjects:
Human insulin precursor
Secretory signal
Truncated α-factor
Full-length α-factor
Pichia pastoris
BMMY
Online Access:https://doi.org/10.1186/s43141-023-00521-w

Internet

https://doi.org/10.1186/s43141-023-00521-w

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