Nanoparticle-delivered multimeric soluble CD40L DNA combined with Toll-Like Receptor agonists as a treatment for melanoma.

Nanoparticle-delivered multimeric soluble CD40L DNA combined with Toll-Like Receptor agonists as a treatment for melanoma.

Stimulation of CD40 or Toll-Like Receptors (TLR) has potential for tumor immunotherapy. Combinations of CD40 and TLR stimulation can be synergistic, resulting in even stronger dendritic cell (DC) and CD8+ T cell responses. To evaluate such combinations, established B16F10 melanoma tumors were inject...

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Bibliographic Details
Main Authors: Geoffrey W Stone, Suzanne Barzee, Victoria Snarsky, Camila Santucci, Brian Tran, Robert Langer, Gregory T Zugates, Daniel G Anderson, Richard S Kornbluth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2754331?pdf=render

Internet

http://europepmc.org/articles/PMC2754331?pdf=render

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