Ischemia-induced endogenous Nrf2/HO-1 axis activation modulates microglial polarization and restrains ischemic brain injury

Ischemia-induced endogenous Nrf2/HO-1 axis activation modulates microglial polarization and restrains ischemic brain injury

Cerebral ischemic stroke accounts for more than 80% of all stroke cases. During cerebral ischemia, reactive oxygen species produced in the ischemic brain induce oxidative stress and inflammatory responses. Nrf2 is a transcription factor responsible for regulating cellular redox balance through the i...

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Bibliographic Details
Main Authors: Ping-Chang Kuo, Wen-Tsan Weng, Barbara A. Scofield, Hallel C. Paraiso, I-Chen Ivorine Yu, Jui-Hung Jimmy Yen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Immunology
Subjects:
ischemic stroke
Nrf2/HO-1 axis
microglia
diabetic stroke
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1440592/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1440592/full

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