High Histone Deacetylase 2/3 Expression in Non-Functioning Pituitary Tumors

High Histone Deacetylase 2/3 Expression in Non-Functioning Pituitary Tumors

Epigenetic modification of chromatin is involved in non-malignant pituitary neoplasia by causing abnormal expression of tumor suppressors and oncogenes. These changes are potentially reversible, suggesting the possibility of targeting tumor cells by restoring the expression of epigenetically silence...

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Bibliographic Details
Main Authors: Wenxiu Zhao, Xiaobin Jiang, Karrin Weisenthal, Jun Ma, Erin M. Botticelli, Yunli Zhou, E. Tessa Hedley-Whyte, Baiyao Wang, Brooke Swearingen, Roy J. Soberman, Anne Klibanski, Xun Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
human clinically non-functioning pituitary adenomas
class I histone deacetylases
growth suppression
epigenetic modifications
regulation of tumor suppressor expressions
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.875122/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.875122/full

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