Macrophage depletion attenuates degeneration of spiral ganglion neurons in kanamycin-induced unilateral hearing loss model

Abstract Pathological conditions in cochlea, such as ototoxicity, acoustic trauma, and age-related cochlear degeneration, induce cell death in the organ of Corti and degeneration of the spiral ganglion neurons (SGNs). Although macrophages play an essential role after cochlear injury, its role in the...

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Bibliographic Details
Main Authors: Mari Dias Shimada, Masao Noda, Ryota Koshu, Yuji Takaso, Hisashi Sugimoto, Makoto Ito, Tomokazu Yoshizaki, Osamu Hori
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-43927-9