Weekly Oral Tenofovir Alafenamide Protects Macaques from Vaginal and Rectal Simian HIV Infection

Weekly Oral Tenofovir Alafenamide Protects Macaques from Vaginal and Rectal Simian HIV Infection

Pre-exposure prophylaxis (PrEP) with a weekly oral regimen of antiretroviral drugs could be a suitable preventative option for individuals who struggle with daily PrEP or prefer not to use long-acting injectables. We assessed in macaques the efficacy of weekly oral tenofovir alafenamide (TAF) at dos...

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Bibliographic Details
Main Authors: Ivana Massud, Kenji Nishiura, Susan Ruone, Angela Holder, Chuong Dinh, Jonathan Lipscomb, James Mitchell, George M. Khalil, Walid Heneine, J. Gerardo Garcίa-Lerma, Charles W. Dobard
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Pharmaceutics
Subjects:
tenofovir alafenamide fumarate (TAF)
tenofovir diphosphate (TFV-DP)
non-human primate (NHP)
HIV prevention
long-acting pre-exposure prophylaxis (LA PrEP)
pharmacokinetics (PK)
Online Access:https://www.mdpi.com/1999-4923/16/3/384

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https://www.mdpi.com/1999-4923/16/3/384

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