The LuxS/AI-2 Quorum-Sensing System of Streptococcus pneumoniae Is Required to Cause Disease, and to Regulate Virulence- and Metabolism-Related Genes in a Rat Model of Middle Ear Infection

The LuxS/AI-2 Quorum-Sensing System of Streptococcus pneumoniae Is Required to Cause Disease, and to Regulate Virulence- and Metabolism-Related Genes in a Rat Model of Middle Ear Infection

Objective:Streptococcus pneumoniae colonizes the nasopharynx of children, and from nasopharynx it could migrate to the middle ear and causes acute otitis media (AOM). During colonization and AOM, the pneumococcus forms biofilms. In vitro biofilm formation requires a functional LuxS/AI-2 quorum-sensi...

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Bibliographic Details
Main Authors: Mukesh K. Yadav, Jorge E. Vidal, Yoon Y. Go, Shin H. Kim, Sung-Won Chae, Jae-Jun Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Streptococcus pneumoniae
LuxS/AI-2
quorum-sensing
luxS mutation
biofilm
in vivo colonization
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2018.00138/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2018.00138/full

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