Recombinant Production of MFHR1, A Novel Synthetic Multitarget Complement Inhibitor, in Moss Bioreactors

Recombinant Production of MFHR1, A Novel Synthetic Multitarget Complement Inhibitor, in Moss Bioreactors

The human complement system is an important part of the immune system responsible for lysis and elimination of invading microorganisms and apoptotic body cells. Improper activation of the system due to deficiency, mutations, or autoantibodies of complement regulators, mainly factor H (FH) and FH-rel...

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Bibliographic Details
Main Authors: Oguz Top, Juliana Parsons, Lennard L. Bohlender, Stefan Michelfelder, Phillipp Kopp, Christian Busch-Steenberg, Sebastian N. W. Hoernstein, Peter F. Zipfel, Karsten Häffner, Ralf Reski, Eva L. Decker
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Plant Science
Subjects:
Physcomitrella patens
moss bioreactor
factor H
plant-made recombinant pharmaceuticals
synthetic complement inhibitor
alternative pathway of complement activation
Online Access:https://www.frontiersin.org/article/10.3389/fpls.2019.00260/full

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https://www.frontiersin.org/article/10.3389/fpls.2019.00260/full

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