Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[<i>b</i>]Thiophene-3-Carboxylate: Synthesis, In Vitro, and In Vivo Activity Evaluation

Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[<i>b</i>]Thiophene-3-Carboxylate: Synthesis, In Vitro, and In Vivo Activity Evaluation

A multicomponent synthesis was empolyed for the synthesis of ethyl 2-amino-4,5,6,7-tetrahydrobenzo[<i>b</i>]thiophene-3-carboxylate <b>1</b>. An interesting cyclization was obtained when the amino-ester <b>1</b> reacted with ethyl isothiocyanate to give the benzo[...

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Bibliographic Details
Main Authors: Emad M. Gad, Mohamed S. Nafie, Elsayed H. Eltamany, Magdy S. A. G. Hammad, Assem Barakat, Ahmed T. A. Boraei
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molecules
Subjects:
benzo[<i>b</i>]thiophene
pyrimidinone
alkylation
MCF-7
HepG-2
JAK2 inhibitor
Online Access:https://www.mdpi.com/1420-3049/25/11/2523

Internet

https://www.mdpi.com/1420-3049/25/11/2523

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