The mechanism of heterogeneous beta-lactam resistance in MRSA: key role of the stringent stress response.

The mechanism of heterogeneous beta-lactam resistance in MRSA: key role of the stringent stress response.

All methicillin resistant S. aureus (MRSA) strains carry an acquired genetic determinant--mecA or mecC--which encode for a low affinity penicillin binding protein -PBP2A or PBP2A'--that can continue the catalysis of peptidoglycan transpeptidation in the presence of high concentrations of beta-l...

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Bibliographic Details
Main Authors: Choonkeun Kim, Michael Mwangi, Marilyn Chung, Catarina Milheiriço, Herminia de Lencastre, Alexander Tomasz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3857269?pdf=render

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http://europepmc.org/articles/PMC3857269?pdf=render

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