Asparagine endopeptidase deficiency mitigates radiation-induced brain injury by suppressing microglia-mediated neuronal senescence

Asparagine endopeptidase deficiency mitigates radiation-induced brain injury by suppressing microglia-mediated neuronal senescence

Summary: Mounting evidence supports the role of neuroinflammation in radiation-induced brain injury (RIBI), a chronic disease characterized by delayed and progressive neurological impairment. Asparagine endopeptidase (AEP), also known as legumain (LGMN), participates in multiple malignancies and neu...

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Bibliographic Details
Main Authors: Ouwen Qiu, Jianyi Zhao, Zhonggang Shi, Huan Li, Siyuan Wang, Keman Liao, Minchao Tang, Jieqiong Xie, Xi Huang, Wenrui Zhang, Li Zhou, Xi Yang, Zhiyi Zhou, Lei Xu, Renhua Huang, Yifeng Miao, Yongming Qiu, Yingying Lin
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:iScience
Subjects:
Molecular biology
Neuroscience
Immunology
Omics
Metabolomics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224009209

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http://www.sciencedirect.com/science/article/pii/S2589004224009209

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