Nonviral overexpression of Scleraxis or Mohawk drives reprogramming of degenerate human annulus fibrosus cells from a diseased to a healthy phenotype

Nonviral overexpression of Scleraxis or Mohawk drives reprogramming of degenerate human annulus fibrosus cells from a diseased to a healthy phenotype

Abstract Background Intervertebral disc (IVD) degeneration is a major contributor to low back pain (LBP), yet there are no clinical therapies targeting the underlying pathology. The annulus fibrosus (AF) plays a critical role in maintaining IVD structure/function and undergoes degenerative changes s...

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Bibliographic Details
Main Authors: Shirley Tang, Connor Gantt, Ana Salazar Puerta, Lucy Bodine, Safdar Khan, Natalia Higuita‐Castro, Devina Purmessur
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:JOR Spine
Subjects:
annulus fibrosus
cell reprogramming
intervertebral disc
low back pain
nonviral transfection
Online Access:https://doi.org/10.1002/jsp2.1270

Internet

https://doi.org/10.1002/jsp2.1270

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