Acute minocycline administration reduces brain injury and improves long-term functional outcomes after delayed hypoxemia following traumatic brain injury

Acute minocycline administration reduces brain injury and improves long-term functional outcomes after delayed hypoxemia following traumatic brain injury

Abstract Clinical trials of therapeutics for traumatic brain injury (TBI) demonstrating preclinical efficacy for TBI have failed to replicate these results in humans, in part due to the absence of clinically feasible therapeutic windows for administration. Minocycline, an inhibitor of microglial act...

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Bibliographic Details
Main Authors: Marta Celorrio, Kirill Shumilov, Camryn Payne, Sangeetha Vadivelu, Stuart H. Friess
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Acta Neuropathologica Communications
Subjects:
Traumatic brain injury
Hypoxemia
Minocycline
Neuroprotection
Secondary injury
Pre-clinical trial
Online Access:https://doi.org/10.1186/s40478-022-01310-1

Internet

https://doi.org/10.1186/s40478-022-01310-1

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