Editing out HIV: application of gene editing technology to achieve functional cure
Abstract Highly active antiretroviral therapy (HAART) successfully suppresses human immunodeficiency virus (HIV) replication and improves the quality of life of patients living with HIV. However, current HAART does not eradicate HIV infection because an HIV reservoir is established in latently infec...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | Retrovirology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12977-021-00581-1 |
| _version_ | 1818873449327624192 |
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| author | Jingna Xun Xinyu Zhang Shuyan Guo Hongzhou Lu Jun Chen |
| author_facet | Jingna Xun Xinyu Zhang Shuyan Guo Hongzhou Lu Jun Chen |
| author_sort | Jingna Xun |
| collection | DOAJ |
| description | Abstract Highly active antiretroviral therapy (HAART) successfully suppresses human immunodeficiency virus (HIV) replication and improves the quality of life of patients living with HIV. However, current HAART does not eradicate HIV infection because an HIV reservoir is established in latently infected cells and is not recognized by the immune system. The successful curative treatment of the Berlin and London patients following bone marrow transplantation inspired researchers to identify an approach for the functional cure of HIV. As a promising technology, gene editing-based strategies have attracted considerable attention and sparked much debate. Herein, we discuss the development of different gene editing strategies in the functional cure of HIV and highlight the potential for clinical applications prospects. Graphical Abstract |
| first_indexed | 2024-12-19T12:54:53Z |
| format | Article |
| id | doaj.art-a535268bbfa446a182728a880440d3d8 |
| institution | Directory Open Access Journal |
| issn | 1742-4690 |
| language | English |
| last_indexed | 2024-12-19T12:54:53Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj.art-a535268bbfa446a182728a880440d3d82022-12-21T20:20:25ZengBMCRetrovirology1742-46902021-12-0118111110.1186/s12977-021-00581-1Editing out HIV: application of gene editing technology to achieve functional cureJingna Xun0Xinyu Zhang1Shuyan Guo2Hongzhou Lu3Jun Chen4Scientific Research Center, Shanghai Public Health Clinical Center, Fudan UniversityScientific Research Center, Shanghai Public Health Clinical Center, Fudan UniversityShanghai Foreign Language School, Shanghai International Studies UniversityDepartment of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan UniversityDepartment of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan UniversityAbstract Highly active antiretroviral therapy (HAART) successfully suppresses human immunodeficiency virus (HIV) replication and improves the quality of life of patients living with HIV. However, current HAART does not eradicate HIV infection because an HIV reservoir is established in latently infected cells and is not recognized by the immune system. The successful curative treatment of the Berlin and London patients following bone marrow transplantation inspired researchers to identify an approach for the functional cure of HIV. As a promising technology, gene editing-based strategies have attracted considerable attention and sparked much debate. Herein, we discuss the development of different gene editing strategies in the functional cure of HIV and highlight the potential for clinical applications prospects. Graphical Abstracthttps://doi.org/10.1186/s12977-021-00581-1HIV/AIDSHighly active antiretroviral therapyGene editingFunctional cure |
| spellingShingle | Jingna Xun Xinyu Zhang Shuyan Guo Hongzhou Lu Jun Chen Editing out HIV: application of gene editing technology to achieve functional cure Retrovirology HIV/AIDS Highly active antiretroviral therapy Gene editing Functional cure |
| title | Editing out HIV: application of gene editing technology to achieve functional cure |
| title_full | Editing out HIV: application of gene editing technology to achieve functional cure |
| title_fullStr | Editing out HIV: application of gene editing technology to achieve functional cure |
| title_full_unstemmed | Editing out HIV: application of gene editing technology to achieve functional cure |
| title_short | Editing out HIV: application of gene editing technology to achieve functional cure |
| title_sort | editing out hiv application of gene editing technology to achieve functional cure |
| topic | HIV/AIDS Highly active antiretroviral therapy Gene editing Functional cure |
| url | https://doi.org/10.1186/s12977-021-00581-1 |
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