Structure based identification and characterization of flavonoids that disrupt human papillomavirus-16 E6 function.

Structure based identification and characterization of flavonoids that disrupt human papillomavirus-16 E6 function.

Expression and function of the human papillomavirus (HPV) early protein 6 (E6) is necessary for viral replication and oncogenesis in cervical cancers. HPV E6 targets the tumor suppressor protein p53 for degradation. To achieve this, "high-risk" HPV E6 proteins bind to and modify the target...

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Bibliographic Details
Main Authors: Jonathan J Cherry, Anne Rietz, Anna Malinkevich, Yuqi Liu, Meng Xie, Matthew Bartolowits, V Jo Davisson, James D Baleja, Elliot J Androphy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3871595?pdf=render

Internet

http://europepmc.org/articles/PMC3871595?pdf=render

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