Primary Extracellular Matrix Enables Long-Term Cultivation of Human Tumor Oral Mucosa Models

3D tumor models clearly outperform 2D cell cultures in recapitulating tissue architecture and drug response. However, their potential in understanding treatment efficacy and resistance development should be better exploited if also long-term effects of treatment could be assessed in vitro. The main...

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Bibliographic Details
Main Authors: Leonie Gronbach, Philipp Jurmeister, Monika Schäfer-Korting, Ulrich Keilholz, Ingeborg Tinhofer, Christian Zoschke
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2020.579896/full