Exploration of the potential causative genes for inflammatory bowel disease: Transcriptome-wide association analysis, Mendelian randomization analysis and Bayesian colocalisation

Exploration of the potential causative genes for inflammatory bowel disease: Transcriptome-wide association analysis, Mendelian randomization analysis and Bayesian colocalisation

Background: Inflammatory bowel disease (IBD) poses a complex challenge due to its intricate underlying mechanisms, and curative treatments remain elusive. Consequently, there is an urgent need to identify genes causally associated with IBD. Methods: We extracted blood eQTL data from the GTExv8.ALL.W...

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Bibliographic Details
Main Authors: Qinghua Luo, Jiawen Wang, Wei Ge, Zihao Li, Yuanting Mao, Chen Wang, Leichang Zhang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Heliyon
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024049752

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http://www.sciencedirect.com/science/article/pii/S2405844024049752

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